1257239-74-9Relevant academic research and scientific papers
Mild and general conditions for Negishi cross-coupling enabled by the use of palladacycle precatalysts
Yang, Yang,Oldenhuis, Nathan J.,Buchwald, Stephen L.
supporting information, p. 615 - 619 (2013/02/23)
A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd0 species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. Copyright
A mild negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides
Luzung, Michael R.,Patel, Jigar S.,Yin, Jingjun
supporting information; experimental part, p. 8330 - 8332 (2011/03/17)
A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd2(dba)3 and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.
