1257313-95-3Relevant academic research and scientific papers
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, SNAr protocol
Rolfe, Alan,Ullah, Farman,Samarakoon, Thiwanka B.,Kurtz, Ryan D.,Porubsky, Patrick,Neuenswander, Benjamin,Lushington, Gerald H.,Santini, Conrad,Organ, Michael G.,Hanson, Paul R.
, p. 653 - 658 (2011)
The development of a microwave-assisted, intermolecular SNAr protocol for the synthesis of a 126-member benzothiaoxazepine-1,1-dioxide library is reported. Diversification of 12 benzothiaoxazepine-1,1-dioxides was achieved in rapid fashion util
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): Multi-gram synthesis of bromo- and fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides
Ullah, Farman,Samarakoon, Thiwanka,Rolfe, Alan,Kurtz, Ryan D.,Hanson, Paul R.,Organ, Michael G.
supporting information; experimental part, p. 10959 - 10962 (2010/11/05)
(Figure Presented). Go with the flow! Using a combination of continuous-flow techniques and microwave irradiation, a 19-member collection of 5-10 gram quantities of benzthiaoxazepine-1,1-dioxides has been produced (see scheme). The elimination of intermediate- and largescale process optimization by invoking the concept of scale-out (rather than scale up) has significantly reduced the time necessary to prepare these compounds.
