125735-97-9Relevant academic research and scientific papers
The synthesis of quinolone natural products from pseudonocardia sp.
Salvaggio, Flavia,Hodgkinson, James T.,Carro, Laura,Geddis, Stephen M.,Galloway, Warren R. J. D.,Welch, Martin,Spring, David R.
supporting information, p. 434 - 437 (2016/02/18)
The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp2-sp3 Suzuki-Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases. The total synthesis of four quinolone natural products is reported. The quinolones were synthesised in a highly efficient and direct manner from various readily prepared quinolone cores and a common boronic ester lateral chain. The key step involved a challenging sp2-sp3 Suzuki-Miyaura reaction.
Iodine mediated addition of trialkylamines to dimethyl acetylenedicarboxylate
Wu, Quanping,Liu, Hui-Fang,Zhang, Yue,Shen, Shiyu,Xue, Song
, p. 617 - 621 (2013/12/04)
Addition reaction of tertiary amines to dimethyl acetylenedicarboxylate mediated by molecular iodine is described. The trialkylamines afford dealkylative adducts in moderate to good yields. Amines containing an aryl group react sluggishly in low yields with a loss of alkyl group.
