1257403-43-2Relevant academic research and scientific papers
A formal total synthesis of fostriecin by a convergent approach
Li, Deyao,Zhao, Yu,Ye, Liu,Chen, Chaonan,Zhang, Jiancun
, p. 3325 - 3331 (2010)
A formal total synthesis of fostriecin has been accomplished in 20 steps. Our method features the derivation of two of the four chiral centers from commercial diethyl d-(+)-malate. The key steps involve the Julia-Kocienski olefination, the Sharpless asymmetric dihydroxylation, and the Stille coupling.
