1257408-80-2Relevant academic research and scientific papers
Synthesis and antimicrobial screening of N-(1-methyl-1H-pyrazole-4- carbonyl)-thiourea derivatives
Nitulescu, George M.,Draghici, Constantin,Chifiriuc, Mariana C.,Marutescu, Luminita,Bleotu, Coralia,Missir, Alexandru V.
, p. 308 - 314 (2012/08/28)
In the search of bioactive molecules in the class of functionally 4-substituted pyrazolic compounds, a series of N-(1-methyl-1H-pyrazole-4- carbonyl)-thiourea derivatives were prepared by addition of various substituted anilines to 1-methyl-1H-pyrazole-4-
Synthesis of new pyrazole derivatives and their anticancer evaluation
Nitulescu, George Mihai,Draghici, Constantin,Missir, Alexandru Vasile
experimental part, p. 4914 - 4919 (2010/12/20)
A series of functionally substituted pyrazole compounds have been synthesized and evaluated in vitro for their antiproliferative effects on a panel of 60 cellular lines, according to the National Cancer Institute screening protocol. Three of the 12 tested compounds showed moderate antitumor activity, one of them being chosen for the 5-dose assay and presented logGI50 values up to -5.75.
