1257413-33-4Relevant articles and documents
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy
Jiao, Guan-Sheng,Kim, Seongjin,Moayeri, Mahtab,Cregar-Hernandez, Lynne,McKasson, Linda,Margosiak, Stephen A.,Leppla, Stephen H.,Johnson, Alan T.
scheme or table, p. 6850 - 6853 (2011/01/04)
Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.