125743-59-1

Basic information

• Product Name: 1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE
• Synonyms: 1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE
• CAS NO: 125743-59-1
• Molecular Formula: C₁₄H₂₀N₂O
• Molecular Weight: 232.32
• Mol File: 125743-59-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE(125743-59-1)
• EPA Substance Registry System: 1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE(125743-59-1)

Safety Data

• Hazardous Substances Data: 125743-59-1(Hazardous Substances Data)

Usage

General Description

1-[4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYL]-ETHANONE is a chemical compound with a specific molecular structure. It contains a methyl-piperazin-1-ylmethyl group attached in the 4th position of a phenyl ring, which is further linked to an ethanone group. This kind of compound is often involved in the synthesis of pharmaceuticals and other organic molecules. Key aspects about this chemical, such as its exact properties, toxicity, and uses, would require more detailed investigation. A CAS registry number would also help to accurately obtain further information, as different chemicals can sometimes share similar names.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 54589-56-9 4-chloromethylacetophenone 
• 51229-51-7 4-acetylbenzyl bromide 
• 1015484-22-6 1-methyl-4-((trifluoro-λ⁴-boranyl)methyl)piperazine potassium 
• 99-90-1 para-bromoacetophenone 
• 99-91-2 para-chloroacetophenone 
• 17201-43-3 4-cyanobenzyl bromide 
• 75-16-1 methylmagnesium bromide 
• 125743-63-7 4-[(4-methyl-1-piperazinyl)methyl]benzonitrile 

Downstream Products

• 125743-60-4 (E)-2-<<1-<4-(4-Methylpiperazin-1-ylmethyl)phenyl>ethylidene>amino>benzonitrile 
• 1204230-96-5 C₂₇H₃₃N₃O₃ 
• 1123622-60-5 tert-butyl (E)-3-(6-{(E)-3-[4-(4-methyl-piperazin-1-yl-methyl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate 
• 1123622-49-0 tert-butyl-(E)-3-(3-{(E)-3-[4-(4-methyl-piperazin-1-yl-methyl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate 
• 125743-61-5 2-(4-<4-Methylpiperazin-1-ylmethyl>phenyl)quinolin-4-amine 

Relevant articles and documents

Preparation method of imidic acid or hydrochloride thereof

The invention relates to a preparation method of imidic acid or hydrochloride thereof, which belongs to the technical field of medicine synthesis. In order to solve the problems of easy salification and low yield in the prior art, the invention provides a preparation method of imidic acid or hydrochloride thereof, which comprises the following steps of in the presence of an acid application agent,reacting 4-halogenated methyl acetophenone with N-methylpiperazine to obtain a corresponding intermediate, under the action of pypocholoride, enabling the intermediate to be subjected to an oxidationreaction to obtain corresponding imidic acid, when the imidic acid hydrochloride is synthesized, after the oxidation reaction is finished, adjusting the pH value to be strongly acidic, so that the corresponding imidic acid hydrochloride is formed. According to the method, the reaction has the effect of high conversion rate during condensation, byproducts of salifying reaction products are effectively avoided, raw material residues can be effectively controlled to be less than 0.2%, and the method has the effect of high product yield.

PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to phenyl thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors

The histone deacetylases (HDACs) are able to regulate gene expression, and histone deacetylase inhibitors (HDACi) emerged as a new class of agents in the treatment of cancer as well as other human disorders such as neurodegenerative diseases. In the prese