1257513-91-9Relevant academic research and scientific papers
An effective synthesis of 5,4′-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction
Matsugi, Masato,Takeda, Masaki,Takahashi, Ayano,Tazaki, Takahide,Tamura, Hiroto,Shioiri, Takayuki
, p. 1107 - 1110 (2010)
A variety of 5,4′-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6- hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4′-alkylflavones.
