1257532-08-3

Upstream product

• 1156032-61-9 ethyl 3-[(S)-1-phenylethylamino]butanoate 
• 2131-55-7 4-Chlorophenyl isothiocyanate 

Downstream Products

• 1257532-21-0 (5S,6R)-5-(4-chlorobenzyl)-3-(4-chlorophenyl)-6-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257532-22-1 (5R,6R)-5-(4-chlorobenzyl)-3-(4-chlorophenyl)-6-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1420778-15-9 3-(4-chlorophenyl)-(S)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)-(R)-6-methyl-1-((S)-1-phenylethyl)-2-thioxotetrahydropyrimidin-4(1H)-one 

Relevant academic research and scientific papers

Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1- phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres

Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1- phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino)butanoate in a one-pot reaction. Benzylation of these substrates illustrated that the orientations of the exocylic and endocylic groups determine the stereochemical outcome of the product formed.