125757-06-4Relevant academic research and scientific papers
Selective Ruthenium-Catalyzed Hydrochlorination of Alkynes: One-Step Synthesis of Vinylchlorides
Dérien, Sylvie,Klein, Hubert,Bruneau, Christian
, p. 12112 - 12115 (2015)
An unprecedented ruthenium-catalyzed direct and selective alkyne hydrochlorination is reported and leads to vinylchlorides in excellent yields with atom economy. The reaction proceeds at room temperature from terminal alkynes and provides a variety of chloroalkenes. Only the regioisomer resulting from the formal Markovnikov addition is selectively formed. Mechanistic studies show the stereoselective syn addition of HCl to alkynes at room temperature and suggest a chloro hydrido RuIV species as a key intermediate of the reaction.
Chloride-tolerant gold(I)-catalyzed regioselective hydrochlorination of alkynes
Ebule, Rene,Liang, Shengzong,Hammond, Gerald B.,Xu, Bo
, p. 6798 - 6801 (2017/11/09)
We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-b
A CONVENIENT PROCEDURE FOR THE SYNTHESIS OF BIS(ETHYNYL)BENZENE DERIVATIVES
Ortaggi, Giancarlo,Sleiter, Giancarlo,D'Ilario, Lucio,Bolasco, Adriana,Chimenti, Franco
, p. 319 - 322 (2007/10/02)
A convenient two-step synthesis of bis(ethynyl)benzenes starting from the corresponding bis(acetyl)derivatives via chlorination of the carbonyl functions with PCl5 followed by dehydrochlorination with sodium amide in liquid ammonia is described.The new compounds obtained have been characterised by spectroscopic and elemental analysis.
