1257585-74-2Relevant academic research and scientific papers
Rapid and Selective Cleavage of Amide Groups at Neutral pH: Applications from Hyaluronic Acid to Small Molecules
Jing, Jing,Bankefors, Johan,Bonneaud, Céline,Sawen, Elin,Gerfaud, Thibaud,Westin, Jonatan,El-Bazbouz, Ghizlane,Kandelin, Lina,Rousseau, Antoine,Olsson, Johan,Karlsson, Anders,Nord, Lars,Bouix-Peter, Claire,Helander Kenne, Anne,Boiteau, Jean-Guy,Tomas, Loic,Hennequin, Laurent,Harris, Craig S.
, p. 2995 - 3000 (2018)
During our investigation to find suitable conditions to prepare very high molecular weight partially de-acetylated hyaluronic acid (HA), we discovered a powerful new method to cleave amide bonds using hydroxylamine salts at neutral pH with remarkable sele
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Shimizu, Yuhei,Noshita, Megumi,Mukai, Yuri,Morimoto, Hiroyuki,Ohshima, Takashi
supporting information, p. 12623 - 12625 (2015/05/20)
Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated. This journal is
HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER
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Page/Page column 59, (2012/04/23)
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.
