125763-63-5

Basic information

• Product Name: Benzene, 1-bromo-4-(1-iodoethyl)-
• CAS NO: 125763-63-5
• Molecular Formula: C8H8BrI
• Molecular Weight: 310.96
• Mol File: 125763-63-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(1-iodoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(1-iodoethyl)-(125763-63-5)
• EPA Substance Registry System: Benzene, 1-bromo-4-(1-iodoethyl)-(125763-63-5)

Safety Data

• Hazardous Substances Data: 125763-63-5(Hazardous Substances Data)

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 125763-64-6 2-(4-Bromo-phenyl)-2,4,5-trimethyl-[1,3]dioxolane 
• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 

Downstream Products

• 257604-11-8 1-(1-azidoethyl)-4-bromobenzene 

Relevant articles and documents

Two-Step Protocol for Iodotrimethylsilane-Mediated Deoxy-Functionalization of Alcohols

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcohols to afford products containing a C?N, C?S, or C?O bond. In the first step the alcohol undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-molecule drugs containing hydroxy-group.

Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes

The preparation of anhydrous hydrogen iodide directly from molecular hydrogen and iodine using a rhodium catalyst is reported for the first time. The anhydrous hydrogen iodide generated was proven to be highly active in the transformations of alkenes, phenyl aldehydes, alcohols, and cyclic ethers to the corresponding iodoalkanes. Therefore, the present methodology not only has provided convenient access to anhydrous hydrogen iodide but also offers a practical preparation method for various iodoalkanes in excellent atom economy.

An expedient stereoselective synthesis of (Z)- and (E)-allyl iodides from Baylis-Hillman adducts along with selective iodination of benzylic alcohols using the polymethylhydrosiloxane-iodine system

A stereoselective method has been developed for the synthesis of (Z)- and (E)-allyl iodides from Baylis-Hillman adducts using polymethylhydrosiloxane (PMHS) and iodine in chloroform at room temperature. In addition, the reagent system has been utilized for the iodination of benzylic alcohols selectively.