1257630-07-1

Basic information

• Product Name: 3-methyl-2-(naphthalen-1-yl)benzaldehyde
• CAS NO: 1257630-07-1
• Molecular Weight: 246.309
• Mol File: 1257630-07-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methyl-2-(naphthalen-1-yl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-(naphthalen-1-yl)benzaldehyde(1257630-07-1)
• EPA Substance Registry System: 3-methyl-2-(naphthalen-1-yl)benzaldehyde(1257630-07-1)

Safety Data

• Hazardous Substances Data: 1257630-07-1(Hazardous Substances Data)

Upstream product

• 109179-31-9 2-bromo-3-methyl-benzaldehyde 
• 13922-41-3 1-Naphthylboronic acid 

Downstream Products

• 1383378-90-2 C₂₅H₁₉N⁽¹⁸⁾O 
• 1383378-47-9 3-methyl-2-(naphthalen-1-yl)benzonitrile 
• 1383378-48-0 7-methyl-3-(p-tolyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-49-1 3-(4-methoxyphenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-50-4 3-(2-methoxyphenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-51-5 7-methyl-3-(4-phenoxyphenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-52-6 7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-53-7 3-(4-chlorophenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-54-8 3-(3-chlorophenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 
• 1383378-56-0 3-mesityl-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one 

Relevant articles and documents

Scalable, Stereocontrolled Formal Syntheses of (+)-Isoschizandrin and (+)-Steganone: Development and Applications of Palladium(II)-Catalyzed Atroposelective C?H Alkynylation

Dibenzocyclooctadiene lignans are an interesting class of molecules because of their unique structure based on an axially chiral biaryl moiety as well as their significant biological activity. Herein, we describe the development of a palladium-catalyzed atroposelective C?H alkynylation and its application in gram-scale, stereocontrolled formal syntheses of (+)-isoschizandrin and (+)-steganone. tert-Leucine was identified as an efficient, catalytic transient chiral auxiliary. A wide range of enantiomerically enriched biaryl compounds were prepared by this approach in good yields (up to 99 %) with excellent enantioselectivity (up to >99 % ee).