1257651-11-8

Basic information

• Product Name: 2,2,6,6-Tetramethyl-1,2,3,6-tetrahydro-4-pyridineboronic acid pinacol ester
• Synonyms: 2,2,6,6-Tetramethyl-1,2,3,6-tetrahydro-4-pyridineboronic acid pinacol ester;1,2,3,6-tetrahydro-2,2,6,6-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2,2,6,6-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydropyridine
• CAS NO: 1257651-11-8
• Molecular Formula: C₁₅H₂₈BNO₂
• Molecular Weight: 265.19932
• Mol File: 1257651-11-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 95-100°C
• Boiling Point: 288.4±50.0 °C(Predicted)
• Appearance: /
• Density: 0.96±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.91±0.60(Predicted)
• CAS DataBase Reference: 2,2,6,6-Tetramethyl-1,2,3,6-tetrahydro-4-pyridineboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,6,6-Tetramethyl-1,2,3,6-tetrahydro-4-pyridineboronic acid pinacol ester(1257651-11-8)
• EPA Substance Registry System: 2,2,6,6-Tetramethyl-1,2,3,6-tetrahydro-4-pyridineboronic acid pinacol ester(1257651-11-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 1
• Hazardous Substances Data: 1257651-11-8(Hazardous Substances Data)

Usage

Uses

1,2,3,6-Tetrahydro-2,2,6,6-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is used as a reagent in the synthesis process of tazemetostat, an EHZ2 inhibitor.

Downstream Products

• 1396771-63-3 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(1-phenylethyl)-6-(2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide 
• 1396771-47-3 1-cyclohexyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide