1257657-59-2Relevant academic research and scientific papers
NON-NATURAL MACROCYCLIC AMIDE HDAC6 INHIBITOR COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
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Page/Page column 7, (2012/10/18)
The present invention relates to novel amide compounds of formula I, and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inh
Non-natural macrocyclic inhibitors of histone deacetylases: Design, synthesis, and activity
Auzzas, Luciana,Larsson, Andreas,Matera, Riccardo,Baraldi, Annamaria,Deschênes-Simard, Benoit,Giannini, Giuseppe,Cabri, Walter,Battistuzzi, Gianfranco,Gallo, Grazia,Ciacci, Andrea,Vesci, Loredana,Pisano, Claudio,Hanessian, Stephen
supporting information; experimental part, p. 8387 - 8399 (2011/02/23)
Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical amino acid residues highly cons
