1257664-75-7Relevant academic research and scientific papers
Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons
Welle, Alexandre,Petrignet, Julien,Tinant, Bernard,Wouters, Johan,Riant, Olivier
supporting information; experimental part, p. 10980 - 10983 (2010/11/21)
(Chemical Equation Presented) Asymmetric aldol reaction: A domino silylation-aldol reaction between enoyloxazolidinones and various aldehydes has been developed (see scheme). The process catalysed by a copper complex in the presence of a borosilane led to high diastereoselectivities. Yields between 59 and 90 % and d.r. values between 78:22 to 95:5 were obtained. When methacryloyloxazolidinones were used, a controlled chiral quaternary carbon was generated. BPin=4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl.
