1257775-94-2Relevant academic research and scientific papers
Succinic acid dihydrazide: A convenient N,N-double block for the synthesis of symmetrical and non-symmetrical succinyl-bis[5-trifluoro(chloro)methyl-1H- pyrazoles]
Bonacorso, Helio G.,Cechinel, Cleber A.,Pittaluga, Everton P.,Ferla, Adriana,Porte, Liliane M. F.,Martins, Marcos A. P.,Zanatta, Nilo
experimental part, p. 1656 - 1663 (2010/11/04)
This paper describes the conventional regioselective synthesis of a series of new succinyl spacer bis-(3,5-substituted 2-pyrazolines and 1H-pyrazoles), namely; 1,4-bis[5-(trifluoromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl] butane-1,4-diones (46-88percent) and the respective dehydrated system (60-78percent), new 1-[5-(trifluoromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutane hydrazides (52-81percent) and the non-symmetrical 2-pyrazolines derivatives thereof as 1-[5-(trifluoromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)-4-(5- (trichloromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl]butane-1,4-diones (75-91percent). All succinyl substituted bispyrazoles were obtained from the cyclocondensation reactions of 4-substituted 4-alkoxy-1,1,1-trihaloalk-3-en-2- ones, where the 4-substituents are H, Me, Ph, 4-FC6H4, 4-ClC6H4, 4-OMeC6H4, 4-NO 2C6H4, 1-naphthyl and 2-furyl, with succinic acid dihydrazide in ethanol as solvent under controlled reaction conditions. -
