1257832-02-2Relevant articles and documents
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase
Talamas, Francisco X.,Abbot, Sarah C.,Anand, Shalini,Brameld, Ken A.,Carter, David S.,Chen, Jun,Davis, Dana,De Vicente, Javier,Fung, Amy D.,Gong, Leyi,Harris, Seth F.,Inbar, Petra,Labadie, Sharada S.,Lee, Eun K.,Lemoine, Remy,Le Pogam, Sophie,Leveque, Vincent,Li, Jim,McIntosh, Joel,Nájera, Isabel,Park, Jaehyeon,Railkar, Aruna,Rajyaguru, Sonal,Sangi, Michael,Schoenfeld, Ryan C.,Staben, Leanna R.,Tan, Yunchou,Taygerly, Joshua P.,Villase?or, Armando G.,Weller, Paul E.
, p. 1914 - 1931 (2014)
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper, we
HETEROCYCLIC ANTIVIRAL COMPOUNDS
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Page/Page column 38, (2010/12/29)
Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
