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N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-2,6-dimethylpyrimidine-4-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1257902-19-4

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1257902-19-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1257902-19-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,7,9,0 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1257902-19:
(9*1)+(8*2)+(7*5)+(6*7)+(5*9)+(4*0)+(3*2)+(2*1)+(1*9)=164
164 % 10 = 4
So 1257902-19-4 is a valid CAS Registry Number.

1257902-19-4Relevant academic research and scientific papers

Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Kim, Jong Yup,Kim, Deukjoon,Kang, Suk Youn,Park, Woo-Kyu,Kim, Hyun Jung,Jung, Myung Eun,Son, Eun-Jung,Pae, Ae Nim,Kim, Jeongmin,Lee, Jinhwa

scheme or table, p. 6439 - 6442 (2010/11/18)

Pyrimidine usually has good pharmacokinetic properties as a drug substance and considerable efforts have been devoted to develop pyrimidine derivatives into drug candidates. Arylpiperazine-containing pyrimidine 4-carboxamide derivatives were synthesized and evaluated for binding to serotonin receptors and transporter. Pyrimidine derivatives showed good antidepressant activity in FST (forced swimming test) animal model and also displayed no appreciable inhibitory activity against hERG channel blocking assay. Herein SAR studies of pyrimidine derivatives targeting serotonin receptors and transporter will be disclosed.

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