1258012-02-0Relevant articles and documents
Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties
Almeida, Bruno,Joglar, Jesus,Luque Rojas, Maria Jesus,Decara, Juan Manuel,Bermudez-Silva, Francisco Javier,Macias-Gonzalez, Manuel,Fito, Montserrat,Romero-Cuevas, Miguel,Farre, Magi,Covas, Maria Isabel,Rodriguez De Fonseca, Fernando,De La Torre, Rafael
, p. 1781 - 1787 (2010)
A series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB1 receptor and/or PPAR-α; part of their biological activity may be caused by these double interactions.