1258074-01-9Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors
Li, Hongmei,Xu, Ruo,Cole, David,Clader, John W.,Greenlee, William J.,Nomeir, Amin A.,Song, Lixin,Zhang, Lili
scheme or table, p. 6606 - 6609 (2010/12/20)
Design and synthesis of cis-2,6-disubstituted N-arylsulfonyl morpholines as novel γ-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. Several different small alkyl groups are installed on the left-hand side to lower the CYP3A4 liability while maintaining excellent in vitro potency.
