1258076-80-0

Basic information

• Product Name: C₈H₈FN
• Synonyms: C₈H₈FN
• CAS NO: 1258076-80-0
• Molecular Weight: 137.157
• Mol File: 1258076-80-0.mol

Chemical Properties

• CAS DataBase Reference: C₈H₈FN(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈FN(1258076-80-0)
• EPA Substance Registry System: C₈H₈FN(1258076-80-0)

Safety Data

• Hazardous Substances Data: 1258076-80-0(Hazardous Substances Data)

Upstream product

• 68285-27-8 3-fluoro-α-methylbenzylamine 

Relevant articles and documents

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

A library of 132 racemic chiral amines (α-substituted methylbenzylamines, benzhydrylamines, 1,2,3,4-tetrahydronaphthylamines (THNs), indanylamines, allylic and homoallylic amines, propargyl amines) was screened against the most versatile monoamine oxidase (MAO-N) variants D5, D9 and D11. MAO-N D9 exhibited the highest activity for most substrates and was applied to the deracemisation of a comprehensive set of selected primary amines. In all cases, excellent enantioselectivity was achieved (e.e. >99%) with moderate to good yields (55–80%). Conditions for the deracemisation of primary amines using a MAO-N/borane system were further optimised using THN as a template addressing substrate load, nature of the enzyme preparation, buffer systems, borane sources, and organic co-solvents.