1258077-75-6Relevant academic research and scientific papers
Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases
Muth, Felix,Günther, Marcel,Bauer, Silke M.,D?ring, Eva,Fischer, Sabine,Maier, Julia,Drückes, Peter,K?ppler, Jürgen,Trappe, J?rg,Rothbauer, Ulrich,Koch, Pierre,Laufer, Stefan A.
supporting information, p. 443 - 456 (2015/07/27)
Tetra-substituted imidazoles were designed as dual inhibitors of c-Jun N-terminal kinase (JNK) 3 and p38α mitogen-activated protein (MAP) kinase. A library of 45 derivatives was prepared and evaluated in a kinase activity assay for their ability to inhibi
Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors
Laufer, Stefan,Hauser, Dominik,Stegmiller, Thomas,Bracht, Claudia,Ruff, Kathrin,Schattel, Verena,Albrecht, Wolfgang,Koch, Pierre
scheme or table, p. 6671 - 6675 (2010/12/19)
The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole seri
