1258078-04-4Relevant articles and documents
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain
Sasikumar,Qiang, Li,Burnett, Duane A.,Greenlee, William J.,Li, Cheng,Heimark, Larry,Pramanik, Birendra,Grilli, Mariagrazia,Bertorelli, Rosalia,Lozza, Gianluca,Reggiani, Angelo
scheme or table, p. 3199 - 3203 (2010/03/03)
Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the