1258206-52-8

Basic information

• Product Name: 3-[2-(4-bromo-phenoxy)-acetylamino]-benzofuran-2-carboxylic acid methyl ester
• CAS NO: 1258206-52-8
• Molecular Weight: 404.217
• Mol File: 1258206-52-8.mol

Chemical Properties

• CAS DataBase Reference: 3-[2-(4-bromo-phenoxy)-acetylamino]-benzofuran-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(4-bromo-phenoxy)-acetylamino]-benzofuran-2-carboxylic acid methyl ester(1258206-52-8)
• EPA Substance Registry System: 3-[2-(4-bromo-phenoxy)-acetylamino]-benzofuran-2-carboxylic acid methyl ester(1258206-52-8)

Safety Data

• Hazardous Substances Data: 1258206-52-8(Hazardous Substances Data)

Upstream product

• 1878-91-7 (4-bromophenoxy)acetic acid 
• 57805-85-3 methyl 3-amino-2-benzofurancarboxylate 

Relevant articles and documents

Synthesis and biological evaluation of 3-substituted-benzofuran-2- carboxylic esters as a novel class of ischemic cell death inhibitors

A series of 3-substituted-benzofuran-2-carboxylic esters was synthesized and evaluated for biological activity as ischemic cell death inhibitors in H9c2 cells and rat primary cardiac myocytes under conditions of oxygen and glucose deprivation. The introduction of a sulfur atom at the three-position substituent of the benzofuran ring markedly improved ischemic cell death inhibitory potency. In particular, 3-[2-(4-nitro-phenylsulfanyl)-acetylamino]-benzofuran-2- carboxylic acid ester (10) (EC50 = 0.532 μM, cell death = 6.18%) and 4-chloro-3-[3-(pyridin-2-ylsulfanyl)-propionylamino]-benzofuran-2-carboxylic ester (18) (EC50 = 0.557 μM, cell death = 7.02%) were shown to be the most potent in this series of benzofuran analogs.