1258215-25-6Relevant articles and documents
Concise, flexible syntheses of 4-(4-imidazolyl)pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors
Toumi, Mathieu,Barbazanges, Marion,Kroll, Sebastian H.B.,Patel, Hetal,Ali, Simak,Coombes, R. Charles,Barrett, Anthony G.M.
supporting information; experimental part, p. 6126 - 6128 (2010/12/24)
A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.