1258221-29-2Relevant academic research and scientific papers
Kharasch-type cyclizations of 2-substituted indole derivatives surprisingly lead to spiroindoles
Van Der Jeught, Sarah,De Vos, Nils,Masschelein, Kurt,Ghiviriga, Ion,Stevens, Christian V.
experimental part, p. 5444 - 5453 (2010/11/18)
Starting from l/H-indole-2-carboxylic acid, a series of spiro[2oxoindole-pyrrolidines] could be synthesized in a straightforward manner. The key reaction is a Kharasch radical cyclization reaction of trichloroacetylated precursors. The identity of the tricyclic final products that were formed could be de-termined as spiro[2-oxoindole-pyrrolidines] by using a combination of different analytical techniques (1H NMR, 13C NMR, gHMBC, HRMS) and additional reactions. The produced skeletons are interesting from a medicinal point of view.
