1258271-67-8Relevant academic research and scientific papers
Facile synthesis of [1,2,3]-triazole-fused isoindolines, tetrahydroisoquinolines, benzoazepines and benzoazocines by palladium-copper catalysed heterocyclisation
Brahma, Kaushik,Achari, Basudeb,Chowdhury, Chinmay
, p. 545 - 555 (2013/04/10)
An elegant method for the synthesis of 1,2,3-triazoles fused with five-, six-, seven- and eight-membered benzoheterocycles, including isoindoline, tetrahydroisoquinoline, benzoazepine and benzoazocine, has been developed via palladium-copper catalysed reactions in one-pot. The broad scope of this reaction was illustrated by effecting bis-heteroannulations, synthesis of uracil derivatives of biological interest, and employment of acetylene gas as an inexpensive substrate. The reactions are experimentally simple and utilise easily accessible substrates of different types. Georg Thieme Verlag Stuttgart · New York.
An easy synthetic approach to 1,2,3-triazole-fused heterocycles
Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela,Iannone, Francesco,Rafaschieri, Giacomo G.
experimental part, p. 8846 - 8853 (2010/11/19)
A convenient synthesis of 1,2,3-triazole-fused isoindolines and dihydroisoquinolines in good to excellent yield is reported, starting from easily available terminal alkynes and (2-haloaryl)alkylazides. The method is based upon a cycloaddition reaction, via click chemistry, followed by a transition metal-catalyzed functionalization of a C-H bond.
