1258276-08-2Relevant articles and documents
Synthesis and biological evaluation of novel hygromycin A antibacterial agents
Visser, Michael S.,Freeman-Cook, Kevin D.,Brickner, Steven J.,Brighty, Katherine E.,Le, Phuong T.,Wade, Sarah K.,Monahan, Rhonda,Martinelli, Gary J.,Blair, Kyle T.,Moore, Dianna E.
, p. 6730 - 6734 (2010)
Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of alkylation and removal of the hydroxyls of the aminocyclitol directed us to a series of alkylated aminocyclitol derivatives with improved Gram-positive activity.