12583-68-5 Usage
Description
Parathyroid hormone (PTH) is an 84 amino acid hormone involved in calcium regulation in counteraction to calcitonin. PTH regulates serum phosphate levels and vitamin D biosynthesis. N-terminal peptides of PTH are used to elicit and study a wide variety of responses in target cells.
Clinical Use
Active fragment (1-34) of endogenous human
parathyroid hormone:
Treatment of osteoporosis in postmenopausal
women and men at increased risk of fractures
Treatment of corticosteroid-induced osteoporosis
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
No metabolism or excretion studies have been performed.
Peripheral metabolism of PTH is believed to occur by
non-specific enzymatic mechanisms in the liver followed
by excretion via the kidneys. The 24-hour urine excretion
of calcium was reduced by a clinically unimportant
amount (15%).
Check Digit Verification of cas no
The CAS Registry Mumber 12583-68-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,5,8 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 12583-68:
(7*1)+(6*2)+(5*5)+(4*8)+(3*3)+(2*6)+(1*8)=105
105 % 10 = 5
So 12583-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C174H278N54O49S2/c1-19-93(16)142(228-156(260)110(46-51-137(243)244)208-167(271)126(82-230)224-168(272)139(90(10)11)225-131(235)73-178)171(275)210-106(42-47-127(179)231)143(247)193-78-133(237)200-111(52-59-278-17)153(257)218-119(68-97-76-188-84-197-97)161(265)219-121(70-129(181)233)163(267)213-114(62-87(4)5)145(249)194-79-132(236)199-101(37-25-28-54-175)146(250)217-118(67-96-75-187-83-196-96)160(264)212-113(61-86(2)3)144(248)195-80-134(238)201-125(81-229)166(270)209-112(53-60-279-18)154(258)206-108(44-49-135(239)240)150(254)204-105(41-32-58-191-174(185)186)155(259)226-140(91(12)13)169(273)211-109(45-50-136(241)242)152(256)216-117(66-95-74-192-100-36-24-23-35-99(95)100)159(263)215-116(64-89(8)9)157(261)205-104(40-31-57-190-173(183)184)148(252)202-102(38-26-29-55-176)147(251)203-103(39-27-30-56-177)149(253)214-115(63-88(6)7)158(262)207-107(43-48-128(180)232)151(255)221-123(72-138(245)246)165(269)227-141(92(14)15)170(274)222-120(69-98-77-189-85-198-98)162(266)220-122(71-130(182)234)164(268)223-124(172(276