125830-40-2

Basic information

• Product Name: 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin
• Synonyms: 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin
• CAS NO: 125830-40-2
• Molecular Weight: 509.943
• Mol File: 125830-40-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin(125830-40-2)
• EPA Substance Registry System: 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin(125830-40-2)

Safety Data

• Hazardous Substances Data: 125830-40-2(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 746639-24-7 4β-iodo-4-O-demethylpodophyllotoxin 
• 16477-16-0 4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin 
• 106636-74-2 1α-bromo-desoxypodophyllotoxin 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 518-28-5 podofilox 

Relevant articles and documents

A one-pot, efficient and facile synthesis of 4β -arylaminopodophyllotoxins: Synthesis of NPF and GL-331 as DNA topoisomerase II inhibitors

A series of 4β-arylamino-4′-O-demethylepipodophyllotoxins and 4β-arylaminopodophyllotoxins have been synthesized with significant stereoselectivity and improved yields by employing the BF3· OEt2/NaI reagent system. Compounds NPF, GL-331 and other DNA topoisomerase II inhibitors have been prepared in good to excellent yields by employing this methodology.

An efficient method for 4β-anilino-4'-demethylepipodophyllotoxins: Synthesis of NPF and W-68

4β-Substituted podophyllotoxin congeners have been obtained with significant stereoselectivity and improved yields by employing Bu4N+I in the displacement reaction of the 4-bromoepipodophyllotoxin. The DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in good yields by this method.