1258304-95-8Relevant articles and documents
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H- benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: D
Hayashi, Shigeo,Nakata, Eriko,Morita, Asato,Mizuno, Kunihiko,Yamamura, Kenzo,Kato, Aki,Ohashi, Katsuyo
, p. 7675 - 7699 (2010)
Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems. Endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor] are located in the centra