1258311-41-9

Basic information

• Product Name: C₁₅H₁₃N₃O₅S
• CAS NO: 1258311-41-9
• Molecular Weight: 347.351
• Mol File: 1258311-41-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₃N₃O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₃N₃O₅S(1258311-41-9)
• EPA Substance Registry System: C₁₅H₁₃N₃O₅S(1258311-41-9)

Safety Data

• Hazardous Substances Data: 1258311-41-9(Hazardous Substances Data)

Upstream product

• 51908-29-3 4-isothiocyanatobenzene sulfonamide 

Relevant articles and documents

The rational design of a novel potent analogue of the 5′-AMP- activated protein kinase inhibitor compound C with improved selectivity and cellular activity

We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5′-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach. Synthesizing only twenty-seven analogues yielded a compound that was equipotent to compound C in the inhibition of the human AMPK (hAMPK) α2 subunit in the heterotrimeric complex in vitro, exhibited significantly improved selectivity against a subset of relevant kinases, and demonstrated enhanced cellular inhibition of AMPK.