1258314-45-2

Upstream product

• 2211-61-2 cis-2-benzoyl-1-cyclohexyl-3-phenyl-aziridine 
• 1206636-18-1 (+/-)-benzyl 5-phenyl-penta-2,3-dienoate 
• 2211-61-2 trans-1-cyclohexyl-2-phenyl-3-benzoylaziridine 
• 2211-61-2 ((2S,3S)-1-Cyclohexyl-3-phenyl-aziridin-2-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Synthesis of pyrroles in supercritical carbon dioxide: Formal [3+2] cycloaddition of 2-benzoyl-aziridines and allenoates

The reactivity of N-benzyl- and N-cyclohexyl-2-benzoyl-3-phenylaziridines toward allenoates in supercritical carbon dioxide (scCO2) is described. The study led to the development of a sustainable and selective approach to pyrrole derivatives an

Reactivity of allenoates towards aziridines: Synthesis of functionalized methylenepyrrolidines and pyrroles

The reactivity of buta-2,3-dienoates towards aziridines is reported. Typically, allenoates react as the 2π-component in the [3+2] cycloaddition with azomethine ylides generated from aziridines, affording 4- methylenepyrrolidines in a site-, regio- and stereoselective fashion. However, N-cyclohexyl- or N-tert-butyl-2-benzoyl-3-phenylaziridines showed a different reactivity in the reaction with buta-2,3-dienoates. Pyrrole derivatives were obtained as single or major products resulting from a formal [3+2] cycloaddition via C-N bond cleavage of the three-membered ring heterocycle leading to functionalized pyrroles. From the reaction with allenoates bearing bulkier C-4 substituents 4-methylenepyrrolidines were also formed as minor products.