1258328-59-4Relevant articles and documents
Formation of multi-stereogenic centers using a catalytic diastereoselective Henry reaction
Arai, Takayoshi,Taneda, Yoshinori,Endo, Yoko
supporting information; experimental part, p. 7936 - 7938 (2011/01/04)
A diastereoselective Henry reaction of chiral aldehydes with nitroalkanes was developed using a chiral sulfonyldiamine (L1)-CuCl complex. The reaction of (R)-2-phenylpropanal and nitromethane was smoothly catalyzed by the (S,S,S)-L1-CuCl complex to give the adduct with 99/1 syn/anti selectivity in 99% ee. In the reaction of (S)-2-phenylpropanal and nitroethane, the (R,R,R)-L1-CuCl catalyst yielded the expected three contiguous stereogenic centers in a highly syn-selective Henry reaction.
