12584-58-6

Basic information

• Product Name: INSULIN
• Synonyms: 8a-l-threonine-10a-l-isoleucine-insulin(ox;insulin(dog);insulin(pig);insulin(spermwhale);insulin,neutral;insulinprocine;neutralinsulin;porcineinsulin
• CAS NO: 12584-58-6
• Molecular Formula: C256H381N65O76S6
• Molecular Weight: 5777.54
• EINECS: 235-703-3
• Product Categories: Insulin Signaling
• Mol File: 12584-58-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• Solubility: It can be solubilized in dilute acetic or hydrochloric acid, pH
• Stability: Hygroscopic
• Merck: 13,5003
• CAS DataBase Reference: INSULIN(CAS DataBase Reference)
• NIST Chemistry Reference: INSULIN(12584-58-6)
• EPA Substance Registry System: INSULIN(12584-58-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: NM8895000
• F: 10
• Hazardous Substances Data: 12584-58-6(Hazardous Substances Data)

Usage

Chemical Properties

White or almost white powder

Uses

Different sources of media describe the Uses of 12584-58-6 differently. You can refer to the following data:
1. Insulin, from porcine pancreas, is used in the determination of the beta-cell reserve during glucose tolerance test or after a carbohydrate rich meal, as a guide for the instauration of insulin therapy, contribution to the diagnosis of insulin and non-insulin-dependent diabetes, characterisation and follow-up of states of glucose intolerance, diagnosis and study of cases of insulin resistance, diagnosis of insulinoma and other causes of hypoglycemia.
2. Hormone; treatment of diabetes mellitus.

Biological Functions

Insulin has anabolic properties that include the stimulation of both skeletal muscle and liver cells to incorporate glucose and convert it to glycogen, to synthesize proteins from amino acids in the blood, and to act on fat cells to enhance their uptake of glucose and the synthesis of fat. In short, insulin encourages anabolism rather than catabolism, because it promotes the synthesis of glycogen, proteins, and lipids. A deficiency of insulin, which characterizes the disease diabetes mellitus (DM), causes extreme changes in the entire metabolic pattern of individuals with DM. Patients with DM often demonstrate elevated blood glucose levels, excess glucose in the urine, and failure to properly utilize carbohydrate and lipids.

InChI:InChI=1/C256H381N65O76S6/c1-29-131(23)205(313-193(337)104-258)251(391)317-204(130(21)22)247(387)288-159(75-82-200(347)348)217(357)282-156(71-78-189(262)333)221(361)308-183-116-401-402-117-184-242(382)305-178(111-323)239(379)294-162(88-123(7)8)224(364)295-168(95-140-53-61-146(327)62-54-140)227(367)283-154(69-76-187(260)331)218(358)290-161(87-122(5)6)222(362)285-158(74-81-199(345)346)220(360)302-174(101-190(263)334)234(374)298-170(97-142-57-65-148(329)66-58-142)230(370)309-182(241(381)304-176(255(396)397)103-192(265)336)115-400-399-114-181(213(353)272-107-194(338)278-153(72-79-197(341)342)216(356)281-151(51-42-84-270-256(266)267)211(351)271-108-195(339)279-166(93-138-46-36-32-37-47-138)226(366)297-167(94-139-48-38-33-39-49-139)229(369)299-171(98-143-59-67-149(330)68-60-143)237(377)320-208(136(28)326)253(393)321-85-43-52-186(321)245(385)286-152(50-40-41-83-257)214(354)277-134(26)254(394)395)311-249(389)203(129(19)20)316-235(375)164(90-125(11)12)292-228(368)169(96-141-55-63-147(328)64-56-141)296-223(363)160(86-12