1258406-64-2Relevant academic research and scientific papers
1,3-Dipolar cycloaddition of 3-alkylsulfanyl-2-arylazo-3-(tert-cycloalkylamino)acrylonitriles with N-methyl- and N-phenylmaleimides
Belskaya, Nataliya P.,Lesogorova, Svetlana G.,Subbotina, Julia O.,Koksharov, Aleksandr V.,Slepukhin, Pavel A.,Dehaen, Wim,Bakulev, Vasiliy A.
, p. 1438 - 1447 (2015)
A series of 1,2-diaza-1,3-butadienes with terminal S,N-acetal function were obtained and reacted with N-methyl- and N-phenylmaleimides. As a result of the 1,3-dipolar cycloaddition, a range of new functionalized nonaromatic heterocyclic compounds including: octahydro-1H-pyrrolo[3,4-a]indolizine, octahydropyrrolo[3′,4′:3,4]pyrrolo[1,2-a]azepine, hexahydropyrrolo[3′,4′:3,4]pyrrolo[2,1-c][1,4]oxazine and -thiazine, were obtained with good yields in mild conditions. Experimental and theoretic results allowed establishment of a relationship between the structures of the tert-cycloalkylamine group and the activity of the azomethine ylides generated.
