1258429-18-3Relevant academic research and scientific papers
Asymmetric total syntheses of spisulosine, its diastereo- and regio-isomers
Dinda, Subal Kumar,Das, Sajal Kumar,Panda, Gautam
experimental part, p. 9304 - 9309 (2011/01/12)
Starting from palmityl alcohol, divergent stereoselective syntheses of spisulosine and its diastereo- and regio-isomers have been achieved. In the Sharpless asymmetric dihydroxylation-based approach, the key step is the synthesis of monoprotected diol, whereas Miyashita's boron-directed C-2 regioselective azidolysis of enantiomerically pure epoxy alcohol is the vital step in the Sharpless asymmetric epoxidation-based route. The latter approach involves the first protecting-group-free synthesis of spisulosine.
