1258512-80-9

Basic information

• Product Name: (S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters
• Synonyms: (S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters
• CAS NO: 1258512-80-9
• Molecular Weight: 404.304
• Mol File: 1258512-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters(1258512-80-9)
• EPA Substance Registry System: (S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters(1258512-80-9)

Safety Data

• Hazardous Substances Data: 1258512-80-9(Hazardous Substances Data)

Upstream product

• 66399-75-5 (S)-2-benzylamino-3-phenyl-propionic acid methyl ester 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 1258513-02-8 (S)-1,5-dibenzyl-4-(tert-butyldiphenylsilyloxy)-3-methyl-1H-pyrrol-2(5H)-one 

Relevant articles and documents

Tetramic acids and derivatives by telluride-triggered dieckmann cyclizations

Treatment of α-bromoacyl amides of esters of N-protected α-amino acids with lithium telluride yields an amide enolate which cyclizes to unstable tetramic acids (2, 4-pyrrolidinediones) which can be converted to stable derivatives (e.g. enol esters, silyl enol ethers, enol tosylates). Reaction conditions are modified to reduce unwanted side reactions: protonation of the enolate, selfcatalyzed intermolecular aldol rections of the tetramic acids, and potential racemization at the α-carbon atom of the amino acid.