1258558-32-5

Basic information

• Product Name: N-(2-(1-hydroxycyclobutyl)phenyl)amine
• Synonyms: N-(2-(1-hydroxycyclobutyl)phenyl)amine
• CAS NO: 1258558-32-5
• Molecular Weight: 163.219
• Mol File: 1258558-32-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-(1-hydroxycyclobutyl)phenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1-hydroxycyclobutyl)phenyl)amine(1258558-32-5)
• EPA Substance Registry System: N-(2-(1-hydroxycyclobutyl)phenyl)amine(1258558-32-5)

Safety Data

• Hazardous Substances Data: 1258558-32-5(Hazardous Substances Data)

Upstream product

• 609-73-4 o-nitroiodobenzene 
• 1258558-31-4 N-(2-(1-hydroxycyclobutyl)phenyl)formamide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1258558-33-6 1-(2-(2,5-dichloropyrimidin-4-ylamino)phenyl)cyclobutanol 
• 1258557-53-7 1-[2-({5-bromo-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}amino)phenyl]cyclobutanol 

Relevant articles and documents

Oxidation of Nonactivated Anilines to Generate N-Aryl Nitrenoids

A low-temperature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycles. The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol percent Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrate the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity, and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

PYRIMIDINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3, A4, X and Y are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora and KDR.