1258596-92-7Relevant academic research and scientific papers
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity
He, Shuwen,Ye, Zhixiong,Dobbelaar, Peter H.,Bakshi, Raman K.,Hong, Qingmei,Dellureficio, James P.,Sebhat, Iyassu K.,Guo, Liangqin,Liu, Jian,Jian, Tianying,Lai, Yingjie,Franklin, Christopher L.,Reibarkh, Mikhail,Holmes, Mark A.,Weinberg, David H.,MacNeil, Tanya,Tang, Rui,Tamvakopoulos, Constantin,Peng, Qianping,Miller, Randy R.,Stearns, Ralph A.,Chen, Howard Y.,Chen, Airu S.,Strack, Alison M.,Fong, Tung M.,Wyvratt Jr., Matthew J.,Nargund, Ravi P.
, p. 6524 - 6532 (2010)
We report an SAR study of MC4R analogs containing spiroindane heterocyclic privileged structures. Compound 26 with N-Me-1,2,4-triazole moiety possesses exceptional potency at MC4R and potent anti-obesity efficacy in a mouse model. However, the efficacy is
