1258599-06-2Relevant academic research and scientific papers
Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling
Nencka, Radim,Sinnaeve, Davy,Karalic, Izet,Martins, Jose C.,Van Calenbergh, Serge
experimental part, p. 5234 - 5246 (2010/12/25)
An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.
