1258602-55-9Relevant academic research and scientific papers
Unexpected reduction of N-hydroxyphthalimides to phthalimides-orthogonal reduction of functionalized N-hydroxyphthalimides
Jacq, Jér?me,Berthiol, Florian,Einhorn, Cathy,Einhorn, Jacques
, p. 2263 - 2266 (2010)
A chemoselective reduction of N-hydroxyphthalimides to phthalimides under mild conditions has been discovered. It involves reaction of an N-hydroxyimide with bis(pinacolato)diboron in the presence of a base. Other easily reducible functional groups, such as iodo, nitro, or azido groups are unaffected. Alternatively, such functional groups may be selectively reduced without affecting the N-hydroxyimide moiety using a set of classical conditions. Georg Thieme Verlag Stuttgart - New York.
