1258631-05-8

Basic information

• Product Name: 8-(2,6-dimethylphenyl)-4-(4-methylpiperazin-1-yl)quinazolin-2-amine
• Synonyms: 8-(2,6-dimethylphenyl)-4-(4-methylpiperazin-1-yl)quinazolin-2-amine
• CAS NO: 1258631-05-8
• Molecular Weight: 347.463
• Mol File: 1258631-05-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-(2,6-dimethylphenyl)-4-(4-methylpiperazin-1-yl)quinazolin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(2,6-dimethylphenyl)-4-(4-methylpiperazin-1-yl)quinazolin-2-amine(1258631-05-8)
• EPA Substance Registry System: 8-(2,6-dimethylphenyl)-4-(4-methylpiperazin-1-yl)quinazolin-2-amine(1258631-05-8)

Safety Data

• Hazardous Substances Data: 1258631-05-8(Hazardous Substances Data)

Upstream product

• 1258630-98-6 8-bromo-4-(4-methylpiperazin-1-yl)quinazolin-2-amine 
• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 1258630-96-4 8-bromo-4-(1H-1,2,4-triazol-1-yl)quinazolin-2-amine 
• 1258630-87-3 N-(8-bromo-4-oxo-3,4-dihydroquinazolin-2-yl)acetamide 
• 1258630-85-1 2-amino-8-bromoquinazolin-4(3H)-one 

Relevant articles and documents

Ligand based design of novel histamine H4 receptor antagonists; Fragment optimization and analysis of binding kinetics

The histamine H4 receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions. In our search for new H4R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl) quinazolin-2-amine (VUF11489), as a new H4R antagonist. Analysis of its binding kinetics at the human H4R showed this compound to have a very different dissociative half-life in comparison with reference antagonist JNJ7777120.