125872-66-4Relevant articles and documents
Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents
Grigolo, Thiago A.,Braga, Carolyne B.,Ornelas, Catia,Russowsky, Dennis,Ferreira-Silva, Guilherme A.,Ionta, Marisa,Pilli, Ronaldo A.
, (2021/09/14)
A library of nine hybrids of 4-hydroxygoniothalamin (2), 4-hydroxypiplartine (4), monastrol (5) and oxo-monastrol (6) was prepared via a modular synthetic route with a diester or a 1,2,3-triazole as linkers. The compounds were assayed against a panel of h
Synthesis of the New Green Fluorescent Protein Chromophore Analogue Starting from a Cinnamic Aldehyde Derivative
Zaitseva,Baranov
, p. 214 - 216 (2019/07/02)
Abstract: A novel derivative of green fluorescent protein chromophore (Z)-5-((E)-3-(4-hydroxyphenyl)allylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one was synthesised. The desired compound was prepared by the synthetic approach based on the use of car
Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
Iwano, Satoshi,Obata, Rika,Miura, Chihiro,Kiyama, Masahiro,Hama, Kazutoshi,Nakamura, Mitsuhiro,Amano, Yoshiharu,Kojima, Satoshi,Hirano, Takashi,Maki, Shojiro,Niwa, Haruki
, p. 3847 - 3856 (2013/07/04)
Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650-900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves.
Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents
Dewal, Mahender B.,Wani, Amit S.,Vidaillac, Celine,Oupicky, David,Rybak, Michael J.,Firestine, Steven M.
, p. 145 - 153 (2012/07/28)
Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant Gram-positiv
Emission wavelength prediction of a full-color-tunable fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one
Kim, Eunha,Koh, Minseob,Lim, Byung Joon,Park, Seung Bum
supporting information; experimental part, p. 6642 - 6649 (2011/06/19)
In this paper we report on a novel fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one, which we named Seoul-Fluor, having tunable and predictable photophysical properties. Using a concise and practical one-pot synthetic procedure, a 68-member library of new fluorescent compounds was synthesized with diverse substituents. In Seoul-Fluor, the electronic characteristics of the substituents, as well as their positional changes, have a close correlation with their photophysical properties. The systematic perturbation of electronic densities on the specific positions of Seoul-Fluor, guided with the Hammett constant, allows emission wavelength tunability covering the full color range. On the basis of these observations and a computational analysis, we extracted a simple first-order correlation of photophysical properties with the theoretical calculation and accurately predicted the emission wavelength of Seoul-Fluors through the rational design. In this study, we clearly demonstrate that Seoul-Fluor can provide a powerful gateway for the generation of desired fluorescent probes without the need for a tiresome synthesis and trial-and-error process.
Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
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Page 26, (2010/02/07)
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: An investigation into the role of the P1' side chain on structure-activity
Young,Payne,Thompson,Gaffin,Lyle,Britcher,Graham,Schultz,Deana,Darke,Zugay,Schleif,Quintero,Emini,Anderson,Huff
, p. 1702 - 1709 (2007/10/02)
A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the benzyl P1' side chain of the Phe-Phe isostere based pseudo peptides 1 (L-682,679) and 2 (L-685,434) with various heteroalkyl groups leads to a series of extremely potent inhibitors of the enzyme. Several examples of the most potent inhibitors were very effective in an ex vivo cell based viral spread assay using human H9 T- lymphocytes and the IIIb isolate of HIV-1. Compound 19 is 120 times more potent than 1 and 16 times more potent than 2 in inhibiting the spread of infection in this assay.
