1258794-26-1

Basic information

• Product Name: 4-BROMO-2-METHYLPHENYL ISOCYANIDE
• Synonyms: HANSA ISN-0727;4-BROMO-1-ISOCYANO-2-METHYLBENZENE;4-BROMO-2-METHYLPHENYL ISOCYANIDE
• CAS NO: 1258794-26-1
• Molecular Formula: C₈H₆BrN
• Molecular Weight: 196.04
• Mol File: 1258794-26-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BROMO-2-METHYLPHENYL ISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLPHENYL ISOCYANIDE(1258794-26-1)
• EPA Substance Registry System: 4-BROMO-2-METHYLPHENYL ISOCYANIDE(1258794-26-1)

Safety Data

• Hazardous Substances Data: 1258794-26-1(Hazardous Substances Data)

Upstream product

• 583-75-5 4-Bromo-2-methylaniline 

Relevant articles and documents

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.