1258845-38-3

Basic information

• Product Name: (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid ethyl ester
• Synonyms: (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid ethyl ester
• CAS NO: 1258845-38-3
• Molecular Weight: 289.126
• Mol File: 1258845-38-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid ethyl ester(1258845-38-3)
• EPA Substance Registry System: (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid ethyl ester(1258845-38-3)

Safety Data

• Hazardous Substances Data: 1258845-38-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 206559-42-4 (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid 
• 60563-13-5 ethyl homovanillate 

Downstream Products

• 206559-42-4 (3-bromo-4-hydroxy-5-methoxyphenyl)acetic acid 
• 1329991-29-8 C₁₈H₁₉BrO₄ 
• 1258845-42-9 (4-acetoxy-3-bromo-5-methoxyphenyl)acetic acid 

Relevant articles and documents

DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.