1258884-53-5

Basic information

• Product Name: ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
• Synonyms: ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
• CAS NO: 1258884-53-5
• Molecular Weight: 446.217
• Mol File: 1258884-53-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate(1258884-53-5)
• EPA Substance Registry System: ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate(1258884-53-5)

Safety Data

• Hazardous Substances Data: 1258884-53-5(Hazardous Substances Data)

Upstream product

• 871700-37-7 N-(2-fluoro-4-iodophenyl)-N'-methylurea 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 29632-74-4 2-fluro-4-iodoaniline 
• 16631-18-8 diethyl 2-methylacetonedicarboxylate 
• 1258884-52-4 2-fluoro-4-iodo-N-((methylimino)methylene)aniline 

Downstream Products

• 1258884-54-6 ethyl 2-(2-fluoro-4-iodophenylamino)-4-methoxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 871700-17-3 trametinib 
• 1400818-95-2 2-(2-fluoro-4-iodophenylamino)-4-methoxy-1,5-dimethyl-6-oxo-N-(2-(vinyloxy)ethoxy)-1,6-dihydropyridine-3-carboxamide 
• 1400818-92-9 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-4-methoxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide 

Relevant articles and documents

Method for synthesizing trametinib

The invention discloses a method for synthesizing trametinib. The method comprises the steps of dehydrating N-(2-fluoro-4-iodophenyl)-N'-methylurea to form carbodiimide, then enabling the product to be subjected to a cyclization reaction with 2-methyl-3-o

NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMIDES AS MEK INHIBITORS

The invention provides novel substituted 6-arylamino pyridone sulfonamides and 6 arylamino pyrazinone sulfonamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans