Nusinersen, commercially known as Spinraza, is a groundbreaking chemical compound specifically engineered to address spinal muscular atrophy (SMA), a rare genetic disorder impacting motor neurons in the spinal cord. It functions by directly targeting the genetic underpinnings of SMA, thereby enhancing the synthesis of the survival motor neuron (SMN) protein, which is essential for the proper functioning of motor neurons. Administered via intrathecal injection into the spinal fluid, Nusinersen ensures that the affected motor neurons receive the treatment they need. Clinical trials have demonstrated its efficacy in improving motor function and decelerating the progression of SMA across various age groups, marking it as the first FDA-approved treatment for this condition. Although its high cost and the necessity for recurrent dosing present challenges, Nusinersen has undeniably transformed the lives of numerous individuals and families grappling with SMA.
1258984-36-9
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Basic information
- Product Name: Nusinersen
- Synonyms: Nusinersen
- CAS NO:1258984-36-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1258984-36-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Nusinersen(CAS DataBase Reference)
- NIST Chemistry Reference: Nusinersen(1258984-36-9)
- EPA Substance Registry System: Nusinersen(1258984-36-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1258984-36-9(Hazardous Substances Data)
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1258984-36-9 Usage
Uses
Used in Pharmaceutical Industry:Nusinersen is used as a therapeutic agent for the treatment of spinal muscular atrophy (SMA) due to its ability to target the genetic cause of the disorder and increase the production of the survival motor neuron (SMN) protein, which is crucial for motor neuron functionality.
Used in Clinical Applications:
Nusinersen is utilized as an intrathecal injection to directly administer the compound into the spinal fluid, ensuring that it reaches and treats the motor neurons affected by SMA. This method of administration has been proven effective in enhancing motor function and slowing the progression of the disease in both infants and older patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1258984-36-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,8,9,8 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1258984-36:
(9*1)+(8*2)+(7*5)+(6*8)+(5*9)+(4*8)+(3*4)+(2*3)+(1*6)=209
209 % 10 = 9
So 1258984-36-9 is a valid CAS Registry Number.
1258984-36-9Upstream product
1258984-36-9Downstream Products
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