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Glaucarubinone, a quassinoid chemical compound, is a natural product derived from various plant species. It is recognized for its potential anti-cancer properties and has been extensively studied for its therapeutic applications against a range of cancers, such as leukemia, breast cancer, and pancreatic cancer. glaucarubinone demonstrates its anti-cancer effects by inducing apoptosis and inhibiting cell proliferation in cancer cells. Furthermore, glaucarubinone exhibits potent anti-protozoal activity, marking it as a significant compound in medical research. However, its use in humans is restricted due to its inherent toxicity.

1259-86-5

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1259-86-5 Usage

Uses

Used in Pharmaceutical Industry:
Glaucarubinone is used as a potential anti-cancer agent for its ability to induce apoptotic cell death and inhibit cell proliferation in various types of cancer cells, including leukemia, breast cancer, and pancreatic cancer.
Used in Medical Research:
Glaucarubinone is used as a compound of interest for its potent anti-protozoal activity, contributing to the development of treatments for protozoal infections.
Due to its toxicity, glaucarubinone's applications are primarily limited to research and development, with the aim of discovering safer and more effective ways to harness its therapeutic potential.

Check Digit Verification of cas no

The CAS Registry Mumber 1259-86-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,5 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1259-86:
(6*1)+(5*2)+(4*5)+(3*9)+(2*8)+(1*6)=85
85 % 10 = 5
So 1259-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H34O10/c1-6-22(4,31)21(30)35-16-15-11(3)17(27)25(32)20-23(5)12(10(2)7-13(26)18(23)28)8-14(34-19(16)29)24(15,20)9-33-25/h7,11-12,14-18,20,27-28,31-32H,6,8-9H2,1-5H3/t11-,12+,14-,15-,16-,17-,18-,20-,22+,23-,24+,25+/m1/s1

1259-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Butyric acid, 2-hydroxy-2-methyl-, 4-ester with 1,3ab,4,7,7aa,11,11a,11ba-octahydro-1a,2a,4b,11b-tetrahydroxy-3a,8,11ab-trimethyl-2H-1,11cb-(epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6abH)-dione

1.2 Other means of identification

Product number -
Other names glaucarubinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1259-86-5 SDS

1259-86-5Upstream product

1259-86-5Downstream Products

1259-86-5Related news

Structure de la glaucarubinone (cas 1259-86-5) nouveau principe amer isole de Simaruba glauca08/11/2019

RésuméUn nouveau principe amer, la Glaucarubinone, a été isolé des graines de Simaruba glauca. Il est montré que cette substance a la formule (IIa).detailed

glaucarubinone (cas 1259-86-5) inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway08/10/2019

p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PAK1 also promotes CRC survival via up-regulation of hypoxia-inducible factor 1α (HIF-1α), a key player in cancer survival. Glaucarubinone, a quassinoid natural prod...detailed

glaucarubinone (cas 1259-86-5) and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases08/09/2019

Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glau...detailed

1259-86-5Relevant academic research and scientific papers

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